I think it's funny that swapping in a LS/LTx is considered more reliable. There must be a bell curve or upside down bell curve with regards to mod and reliability for these vehicles. A maxim I have found that generally holds true is that the more you deviate from stock, the less reliable a vehicle is, regardless of platform. I would think this holds true even on the N54, until you look to go over 600whp with a big single. It can be argued that a single is more reliable than hybrid twins, but I think there are other tradeoffs like o2 sensors, etc.
I'm curious though, other than because no one else has done the LTx, what is having you consider that route? It seems if reliability is your main concern, you'd go with a proven, oft repeatable choice in an LSx. Not saying the LTx isn't reliable, it's just new, and often times you don't blaze a trail when looking for reliability. If I really wanted a super high hp E90, I would grab a 4.8 or 5.3 and slap a ginormous turbo on it and make 1000+ whp and be done. Sadly, what brought me to this platform is the thing most want to get rid of - the twin turbo inline 6. I LOVE the fact that on pump gas, my little 3 liter will smoke my buddy's 500 rwp bic cammin v8. I go surging past him as quiet as can be, while his car is creating a giant racket. Different strokes for different folks!